37450 - 動態(tài)足底觸覺儀
動態(tài)足底觸覺儀是用以自動評估嚙齒類動物跖面的“觸覺感應(yīng)”。它與電子觸覺測量（Electronic Von Frey ）和足底觸覺測量（Plantar Von Frey ）類似，不同之處在于它能記錄持續(xù)時(shí)間和爪縮回時(shí)的作用力。
可移動的觸覺刺激裝置放于實(shí)驗(yàn)動物足底，可根據(jù)實(shí)驗(yàn)人員需要設(shè)定力的大小和力增大的速度等。
觸覺測量套件（ Von Frey ）以每次增加直徑0.05mm的細(xì)絲增加施力，直到受試動物的爪抽搐。
動態(tài)足底觸覺計(jì)的新模式為：
一臺可移動的觸覺刺激裝置，配備刺激絲和可調(diào)整角度的鏡子；
實(shí)為一微電子處理單位，提供數(shù)字顯示、內(nèi)部數(shù)據(jù)存儲、可用閃存導(dǎo)出數(shù)據(jù)、可外接打印機(jī)；
寬敞的實(shí)驗(yàn)操作平臺；
模塊化的動物籠，可自由組合3-12個(gè)隔間。
| 特征 | 優(yōu)點(diǎn) |
| 儀器自動施力 | 施力速度、方向等保持一致性 |
| 操作人員只需按動開關(guān) | 相比用Von Frey測試，本實(shí)驗(yàn)時(shí)間短，且操作人員不會感到沉悶 |
| 力的大小和增加量可預(yù)置 | 更多參數(shù)符合實(shí)驗(yàn)需要 |
規(guī)格：
| 開始： | 軟鍵 |
| 可設(shè)力范圍： | 0 - 50.0 g, 分辨率為0.5 g |
| 可設(shè)力增加率： | 1 - 50 s, 分辨率為1s |
| 著力絲移動范圍； | 12 mm |
| 實(shí)驗(yàn)時(shí)間： | 液晶屏顯示，分辨率為0.1s |
| 連接電腦： | DELTA 9-pin 連接線 |
| 電源： 規(guī)格： 動物罩子： | 85-264 VAC - 50-60Hz - 20 W max 85 x 40 x 40 cm 3個(gè)，每個(gè)20x20x14(h) cm |
| 凈重： | 12.50 Kg. |
| 毛重： 包裝規(guī)格： | 約21.50 Kg 98x49x47cm |
附件：
| 37000-145： | 面板內(nèi)嵌式熱敏打印機(jī) |
| 57145： 37450-278 37100 | 微型熱敏打印機(jī) 外加刺激，穿孔平臺和動物保護(hù)罩 兩組Durham動物抓持器，針對面部疼痛實(shí)驗(yàn) |
參考文獻(xiàn)：
提及動態(tài)足底觸覺儀的文獻(xiàn)：
- R. Lu, A. Schmidtko: “Direct Intrathecal Drug Delivery in Mice for Detecting In Vivo Effects of cGMP on Pain Processing” Methods in Molecular Biology 1020: 215-221, 2013
- I.Q. Russe et alia: “Activation of the AMP-Activated Protein Kinase Reduces Inflammatory Nociception” Journal of Pain 2, 2013
- J. Btesh et alia: “Mapping the Binding Site of TRPV1 on AKAP79: Implications for Inflammatory Hyperalgesia” J. Neuroscience 33 (21): 9184-9193, 2013
- V. Brázda et alia: “Dynamic Response to Peripheral Nerve Injury Detected by In Situ Hybridization of IL-6 and its Receptor mRNAs in the Dorsal Root Ganglia is not Strictly Correlated With Signs of Neuropathic Pain” Molecular Pain 9(42), 2013
- V. Shunmugavel et alia: “Simvastatin Ameliorates Cauda Equina Compression Injury in a Rat Model of Lumbar Spinal Stenosis” J. Neuroimmune Pharmacology 8 (1): 274-286, 2013
- O. Coste et alia: “The p21-activated kinase PAK 5 is involved in formalin-induced nociception through regulation of MAP-kinase signaling and formalin-specific receptors” Behavioural Brain Research 234 (1): 121-128, 2012
- M.K. Boettger et alia: “Differential Effects of Locally and Systemically Administered Soluble Glycoprotein 130 on Pain and Inflammation in Experimental Arthritis” Arthritis Research & Therapy 12 (R140): 1-9, 2010
- A.L.M. Scott and M.S. Ramer: ” Schwann Cell p75NTR Prevents Spontaneous Sensory Reinnervation of the Adult Spinal Cord” Brain: 1-12, 2010
- M. Rosemann et alia: “Microphthalmia, Parkinsonism, and Enhanced Nociception in Pitx3416insG Mice” Mamm Genome 21: 12-27, 2010- D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”.Nature NSC, 2010
- L. Ramer et alia: "Rho-Kinase Inhibition Enhances Axonal plasticity and Attenuates Cold Hyperalgesia after Dorsal Rhizotomy" J. Neuroscience, 24 (48), 10796-10805, 2004
- E. Escribano et alia: "Rapid Human Skin Permeation and Topical Anaesthetic Activity of a New Amethocaine Microemulsion" Skin Pharmacol. Physiol., 18, 294-300, 2004
- G. Villetti et alia: "Antinociceptive Activity of the N-Methyl-D-aspartate Receptor Antagonist N-(2-Indanyl)-glycinamide Hydrochloride (CHF3381) in Experimental Models of Inflammatory and Neuropathic Pain" J. Pharmacol. Exper. Therap., 306, 804-814, 2003
- M. Isabel Arévalo et alia: "Thermal Hyperalgesia and Light Touch Allodynia After Intradermal Mycobacterium butyricum Administration in Rat" Inflammation, 27 (5), 293-299, 2003
Durham Holders for Orofacial Stimulation
- F.G. Garrett, P.L. Durham et alia: “Validation of a Novel Rat-Holding Device for studying heat- and mechanical-Evoked Trigeminal Nocifensive Behavioral Responses” J. Orofacial Pain, 26 (4): 336- 344,2012
- F.G. Garrett, P.L. Durham et alia: “Development of a novel device for measuring withdrawal latency by thermal stimulation in rodent facial pain models using the Hargreaves Plantar Apparatus” Poster presented at SFN 2010
